HCN1

Across TCGA patient cohorts, HCN1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,700 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HCN1-associated proteins across cancer lineages are RBSN, PRKAR2B, and AP2B1. Each is linked with HCN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HCN1-to-partner and partner-to-HCN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCN1 versus RBSN in GBM, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN1→partner) and Y-score (partner→HCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RBSN →	+0.227	+0.903	<.001	<.001	3	3
GBM	PRKAR2B →	+0.674	+0.683	<.001	<.001	3	3
GBM	AP2B1 →	+0.274	+0.722	<.001	<.001	3	3
GBM	BTBD8_S366 →	+0.842	+0.824	<.001	<.001	3	3
BRCA	GDAP1_S11 →	+1.233	+0.070	<.001	<.001	3	3
GBM	ANGEL2 →	+0.284	+0.976	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,700 associations by consensus.

HCN1 vs RBSN — GBM

Explore this scatter interactively →