HCN1

Across TCGA pan-cancer cohorts, HCN1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated HCN1 data layer compared with 11 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher HCN1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HCN1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and PAAD show a favorable association.

MESO, THCA, and LIHC are the cancer types where HCN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.400	0.705	<.001	70	view →
THCA	OS	Median	All	0.895	0.981	.006	52	view →
LIHC	OS	Median	II,III,IV	0.270	0.552	<.001	39	view →
THYM	DFS	Quartile	All	0.656	0.929	.001	37	view →
ESCA	OS	Quartile	II,III,IV	0.670	0.397	.005	36	view →
PAAD	DFS	Quartile	II,III,IV	0.555	0.361	.010	31	view →
ACC	OS	Tertile	All	0.692	0.969	.006	27	view →
BRCA	OS	Tertile	IV	0.799	0.285	.004	27	view →
LGG	DFS	Median	All	0.795	0.654	.006	24	view →
SCLC	OS	Quartile	IV	0.164	0.644	.003	18	view →
OV	OS	Tertile	All	0.885	0.810	.008	16	view →
KIRC	OS	Tertile	II,III,IV	0.710	0.831	.014	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

HCN1–MESO (OS)

Open the MESO breakdown →