HCN1

Across TCGA pan-cancer cohorts, HCN1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HCN1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HCN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HCN1 is over-expressed in tumor, although a few such as BRCA and BLCA show the opposite, repressed pattern.

COAD, BRCA, and BLCA are the cancer types where HCN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HCN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.298	<.001	6	view →
BRCA	All	II,III,IV	−0.217	<.001	6	view →
BLCA	All	III,IV	−0.032	.028	3	view →
LUAD	Female	All	+0.302	.032	2	view →
STAD	All	II,III,IV	−0.207	.009	2	view →
LUSC	Male	III,IV	−0.092	.008	2	view →
PRAD	All	All	−0.017	.044	2	view →
CHOL	All	All	−0.107	.028	1	view →
THCA	Female	All	−0.021	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HCN1–COAD

Open the COAD breakdown →