HCN1

Across TCGA patient cohorts, HCN1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,052 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HCN1-associated genes across cancer lineages are PRODH, SOX10, and SEPTIN3. Each is linked with HCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCN1-to-partner and partner-to-HCN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCN1 versus PRODH in GBM, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN1→partner) and Y-score (partner→HCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+0.632	+0.412	.002	<.001	3	1
GBM	SOX10 →	+1.394	+0.369	.001	.001	3	1
GBM	SEPTIN3 →	+0.830	+0.437	<.001	<.001	3	1
GBM	TPTEP1 →	+0.750	+0.461	.003	<.001	3	1
GBM	SLC5A4 →	+0.656	+0.437	<.001	<.001	3	1
GBM	RASL10A →	+0.636	+0.508	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,052 associations by consensus.

HCN1 vs PRODH — GBM

Explore this scatter interactively →