HCN1

Across TCGA patient cohorts, HCN1 mutation is significantly associated with the RNA expression of many other genes, with 7,994 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCN1-associated genes across cancer lineages are BUB3, PSRC1, and ZNHIT3. Each is linked with HCN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both HCN1-to-partner and partner-to-HCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by HCN1-low versus HCN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN1→partner) and Y-score (partner→HCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.468	+1.353	<.001	<.001	3	6
UCEC	PSRC1 →	+0.501	+1.947	<.001	<.001	3	6
UCEC	ZNHIT3 →	+0.428	+1.729	<.001	<.001	3	5
STAD	ACTR6 →	+0.445	+3.372	.003	.004	3	5
SKCM	NELFE →	+0.213	+1.534	.007	.005	3	5
LUSC	VRK1 →	+0.376	+1.068	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,994 associations by consensus.

BUB3 by HCN1 expression — UCEC

Explore this box plot interactively →