HCN1

Across TCGA cell cohorts, HCN1 mutation is significantly associated with the RNA expression of many other genes, with 431 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HCN1-associated genes across cancer lineages are HACD3, SAMM50, and BUB3. Each is linked with HCN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HCN1-to-partner and partner-to-HCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HACD3 grouped by HCN1-low versus HCN1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN1→partner) and Y-score (partner→HCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HACD3 →	+0.518	+3.160	.002	.006	3	3
LARGE_INTESTINE	SAMM50 →	+0.568	+3.386	<.001	.001	3	2
LARGE_INTESTINE	BUB3 →	+0.466	+3.067	.003	.009	3	2
LARGE_INTESTINE	MRPL39 →	+0.589	+3.082	.001	.007	3	2
LARGE_INTESTINE	PTTG1 →	+0.552	+3.169	.008	.009	3	2
LARGE_INTESTINE	GLOD4 →	+0.557	+2.451	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 431 associations by consensus.

HACD3 by HCN1 expression — LUNG_SCLC

Explore this box plot interactively →