HCAR3

Across TCGA patient cohorts, HCAR3 protein abundance is significantly associated with the RNA expression of many other genes, with 151 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HCAR3-associated genes across cancer lineages are NFKBIA, RABGGTA, and RNF125. Each is linked with HCAR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCAR3-to-partner and partner-to-HCAR3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCAR3 versus NFKBIA in LSCC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCAR3→partner) and Y-score (partner→HCAR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NFKBIA →	+0.538	+0.946	.004	.003	3	1
LSCC	RABGGTA →	+0.507	+1.124	.003	.002	3	1
LSCC	RNF125 →	-0.800	-1.406	.003	.001	3	1
LSCC	HAS3 →	+1.748	+1.310	.005	.002	3	1
LSCC	C12orf57 →	-0.608	-1.405	.001	<.001	3	1
LSCC	TRAK2 →	-0.559	-1.504	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 151 associations by consensus.

HCAR3 vs NFKBIA — LSCC

Explore this scatter interactively →