HCAR3

Across TCGA pan-cancer cohorts, HCAR3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HCAR3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HCAR3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HCAR3 is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where HCAR3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HCAR3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.772	<.001	7	view →
LUAD	Male	II,III,IV	−1.127	<.001	6	view →
BRCA	All	III,IV	−1.049	<.001	6	view →
KICH	All	All	+0.675	.006	5	view →
THCA	Male	All	+0.205	.005	4	view →
READ	All	III,IV	+1.100	.043	2	view →
PRAD	All	All	−0.650	<.001	2	view →
BLCA	All	III,IV	+1.100	.042	1	view →
LUSC	Male	All	+0.479	.039	1	view →
LIHC	All	II,III,IV	+0.240	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HCAR3–COAD

Open the COAD breakdown →