HBZ

Across TCGA patient cohorts, HBZ mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HBZ-associated genes across cancer lineages are MIR5582, TRAJ28, and RPS3AP33. Each is linked with HBZ in more than 1 cancer types. Because this analysis shows association rather than direction, both HBZ-to-partner and partner-to-HBZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5582 grouped by HBZ-low versus HBZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBZ→partner) and Y-score (partner→HBZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR5582 →	+0.901	+3.717	<.001	.003	3	1
UCEC	TRAJ28 →	+0.800	+3.717	.001	.003	3	1
UCEC	RPS3AP33 →	+0.059	+3.525	.005	.008	3	1
UCEC	NPS →	+0.448	+4.722	<.001	.004	3	1
UCEC	LINC01399 →	+0.283	+3.679	.002	.007	3	1
UCEC	CYP4F44P →	+0.132	+4.771	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MIR5582 by HBZ expression — UCEC

Explore this box plot interactively →