HBZ

Across TCGA pan-cancer cohorts, HBZ RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated HBZ data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher HBZ RNA is associated with better overall survival. In most high-consensus cancer types, elevated HBZ expression acts as an unfavorable survival marker, although some lineages such as STAD and READ show a favorable association.

STAD, LUSC, and KIRP are the cancer types where HBZ RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	III,IV	0.790	0.410	.016	36	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
KIRP	OS	Tertile	All	0.776	0.912	<.001	27	view →
MESO	OS	Quartile	III,IV	0.204	0.753	.021	18	view →
READ	DFS	Tertile	III,IV	1.000	0.296	.015	18	view →
PRAD	DFS	Median	All	0.825	0.918	<.001	18	view →
SKCM	DFS	Median	IV	0.111	0.694	.004	9	view →
ESCA	DFS	Tertile	All	0.353	0.535	.023	9	view →
BRCA	OS	Quartile	All	0.957	0.918	.021	8	view →
BLCA	OS	Tertile	All	0.812	0.285	.020	6	view →
ACC	DFS	Tertile	III,IV	0.261	0.618	.010	6	view →
UVM	OS	Tertile	III,IV	0.933	0.597	.034	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

HBZ–STAD (OS)

Open the STAD breakdown →