Across TCGA patient cohorts, HAPLN4 mutation is significantly associated with the RNA expression of many other genes, with 571 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAPLN4-associated genes across cancer lineages are RNU6-686P, MIR629, and RNU6-1246P. Each is linked with HAPLN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both HAPLN4-to-partner and partner-to-HAPLN4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAPLN4→partner) and Y-score (partner→HAPLN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-686P →	+0.668	+5.435	<.001	.005	3	3
HNSC	MIR629 →	+0.578	+5.069	<.001	.008	3	3
HNSC	RNU6-1246P →	+0.431	+6.763	<.001	<.001	3	3
SKCM	RNU6-863P →	+0.606	+4.339	<.001	<.001	3	3
CESC	H3P18 →	+0.649	+4.539	.006	.008	3	2
CESC	RNA5SP20 →	+0.486	+4.705	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 571 associations by consensus.

Exploration

HAPLN4 survival (RNA) · tumor vs normal (RNA) · all HAPLN4 data types