Across TCGA pan-cancer cohorts, HAPLN4 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of HAPLN4’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where HAPLN4 RNA is repressed in tumor relative to normal tissue. In most cancer types HAPLN4 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

BRCA are the cancer types where HAPLN4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HAPLN4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	−0.002	.010	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: HAPLN4 RNA expression & survival · all HAPLN4 data types