HAPLN3

Across TCGA patient cohorts, HAPLN3 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,029 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HAPLN3-associated proteins across cancer lineages are GBP5, FMNL1, and GIMAP4. Each is linked with HAPLN3 in more than 8 cancer types. Because this analysis shows association rather than direction, both HAPLN3-to-partner and partner-to-HAPLN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HAPLN3 versus GBP5 in BRCA, with a Pearson correlation of 0.66.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HAPLN3→partner) and Y-score (partner→HAPLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GBP5 →	+1.098	+1.452	<.001	<.001	3	9
LSCC	FMNL1 →	+0.573	+0.714	<.001	<.001	3	8
HNSC	GIMAP4 →	+0.709	+0.893	<.001	<.001	3	8
BRCA	TAPBP →	+0.595	+1.336	<.001	<.001	3	8
BRCA	PARP14 →	+0.460	+1.408	<.001	<.001	3	8
CCRCC	PSMB7 →	-0.421	-0.598	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,029 associations by consensus.

HAPLN3 vs GBP5 — BRCA

Explore this scatter interactively →