HAPLN3

Across TCGA patient cohorts, HAPLN3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAPLN3-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and A-Raf_pS299. Each is linked with HAPLN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAPLN3-to-partner and partner-to-HAPLN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by HAPLN3-low versus HAPLN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAPLN3→partner) and Y-score (partner→HAPLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.709	+2.604	.002	.005	3	2
UCEC	EGFR_pY1068 →	-0.281	-2.502	.004	.002	3	1
UCEC	A-Raf_pS299 →	-0.133	-2.000	.004	.030	3	1
UCEC	ERK2 →	+0.233	+2.807	.002	.003	3	1
UCEC	FoxM1 →	+0.222	+2.000	.029	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.174	-2.584	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Caspase-7-cleavedD198 by HAPLN3 expression — UCEC

Explore this box plot interactively →