HAO2

Across TCGA patient cohorts, HAO2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAO2-associated genes across cancer lineages are TFRC, Mre11, and PCNA. Each is linked with HAO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HAO2-to-partner and partner-to-HAO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by HAO2-low versus HAO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAO2→partner) and Y-score (partner→HAO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.765	+3.459	<.001	.005	3	3
UCEC	Mre11 →	-0.076	-3.140	.024	.019	3	2
UCEC	PCNA →	+0.277	+3.321	.001	.009	3	2
UCEC	Bak →	+0.236	+3.321	.016	.009	3	2
UCEC	BRCA2 →	-0.126	-3.126	.011	.018	3	2
SKCM	Caveolin-1 →	-0.585	-1.874	.013	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

TFRC by HAO2 expression — UCEC

Explore this box plot interactively →