HAO2

Across TCGA pan-cancer cohorts, HAO2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of HAO2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where HAO2 RNA is repressed in tumor relative to normal tissue. In most cancer types HAO2 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and LIHC are the cancer types where HAO2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HAO2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	−6.726	<.001	11	view →
KICH	Male	II,III,IV	−6.333	<.001	10	view →
LIHC	Female	II,III,IV	−4.831	<.001	8	view →
KIRC	Male	All	−1.906	<.001	8	view →
CHOL	Female	All	−7.680	<.001	5	view →
THCA	Male	All	−0.062	.015	5	view →
PRAD	All	All	−0.058	.020	2	view →
BLCA	Female	III,IV	−0.088	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

HAO2–KIRP

Open the KIRP breakdown →