HAND2

Across TCGA patient cohorts, HAND2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAND2-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, NF2, and eEF2. Each is linked with HAND2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAND2-to-partner and partner-to-HAND2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by HAND2-low versus HAND2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAND2→partner) and Y-score (partner→HAND2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.517	+2.584	.029	.011	3	2
UCEC	NF2 →	+0.253	+3.000	.012	.036	3	2
UCEC	eEF2 →	+0.487	+3.000	.003	.036	2	2
UCEC	EGFR_pY1068 →	-0.390	-3.459	<.001	.005	3	1
UCEC	A-Raf_pS299 →	-0.133	-3.169	.017	.019	3	1
UCEC	INPP4B →	-0.451	-3.584	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Acetyl-a-Tubulin-Lys40 by HAND2 expression — UCEC

Explore this box plot interactively →