HAND2

Across TCGA cell cohorts, HAND2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,862 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HAND2-associated GO terms across cancer lineages are DNA-templated transcription initiation, Positive regulation of secretion by cell, and Positive regulation of secretion. Each is linked with HAND2 in more than 7 cancer types. Because this analysis shows association rather than direction, both HAND2-to-partner and partner-to-HAND2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription initiation grouped by HAND2-low versus HAND2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HAND2→partner) and Y-score (partner→HAND2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA-templated transcription initiation →	+0.075	+2.068	.003	.007	3	8
BONE	Positive regulation of secretion by cell →	-0.073	-2.878	<.001	.002	3	7
BONE	Positive regulation of secretion →	-0.069	-2.921	.001	.002	3	7
BONE	Regulation of sodium ion transmembrane transporter activity →	-0.181	-2.558	.007	.006	2	7
OVARY	Regulation of nucleotide-excision repair →	+0.084	+1.095	<.001	.001	3	6
BONE	Actin filament-based movement →	-0.094	-2.282	.003	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,862 associations by consensus.

DNA-templated transcription initiation by HAND2 expression — BONE

Explore this box plot interactively →