HAND2

Across TCGA cell cohorts, HAND2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HAND2-associated genes across cancer lineages are GDF3, OR2L8, and AVP. Each is linked with HAND2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAND2-to-partner and partner-to-HAND2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GDF3 grouped by HAND2-low versus HAND2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAND2→partner) and Y-score (partner→HAND2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GDF3 →	+0.013	+5.643	<.001	.002	3	1
LUNG_SCLC	OR2L8 →	+0.155	+5.029	<.001	.006	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
LARGE_INTESTINE	MSGN1 →	+0.056	+3.345	.007	.007	3	1
LARGE_INTESTINE	OR2AT4 →	+0.015	+3.196	.006	.007	3	1
LARGE_INTESTINE	DAZ4 →	+0.164	+3.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GDF3 by HAND2 expression — LUNG_SCLC

Explore this box plot interactively →