HAND2

Across TCGA cell cohorts, HAND2 mutation is significantly associated with the mutation status of many other genes, with 2,109 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HAND2-associated genes across cancer lineages are MYH6, PRRC2B, and EXT1. Each is linked with HAND2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HAND2-to-partner and partner-to-HAND2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH6 grouped by HAND2-low versus HAND2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAND2→partner) and Y-score (partner→HAND2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYH6 →	+2.779	+4.326	.006	.006	1	4
LARGE_INTESTINE	PRRC2B →	+1.874	+3.700	.005	.005	1	4
BLOOD_Lymphoma	EXT1 →	+5.014	+5.584	.003	.003	1	4
LARGE_INTESTINE	ATXN2 →	+2.781	+4.504	<.001	<.001	1	4
BLOOD_Lymphoma	KL →	+4.014	+4.969	.008	.008	1	4
STOMACH	KAT6A →	+4.807	+4.807	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,109 associations by consensus.

MYH6 by HAND2 expression — BLOOD_Leukemia

Explore this box plot interactively →