HAGHL

Across TCGA patient cohorts, HAGHL mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAGHL-associated genes across cancer lineages are RPL23AP45, RPL36AP35, and OR5AO1P. Each is linked with HAGHL in more than 1 cancer types. Because this analysis shows association rather than direction, both HAGHL-to-partner and partner-to-HAGHL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP45 grouped by HAGHL-low versus HAGHL-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAGHL→partner) and Y-score (partner→HAGHL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RPL23AP45 →	+0.068	+5.305	<.001	.003	3	2
BLCA	RPL36AP35 →	+0.184	+7.640	<.001	.009	3	2
LIHC	OR5AO1P →	+0.177	+4.822	<.001	.003	3	1
LIHC	MIR5088 →	+0.336	+5.902	<.001	.001	3	1
UCEC	AQP7P4 →	+0.096	+4.442	<.001	.007	3	1
UCEC	MIR7702 →	+0.757	+6.475	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

RPL23AP45 by HAGHL expression — LIHC

Explore this box plot interactively →