HAGHL

Across TCGA pan-cancer cohorts, HAGHL RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of HAGHL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where HAGHL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HAGHL is over-expressed in tumor.

KICH, COAD, and BLCA are the cancer types where HAGHL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HAGHL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	III,IV	+3.650	<.001	11	view →
COAD	All	IV	+3.095	<.001	11	view →
BLCA	Male	All	+1.361	<.001	11	view →
THCA	Male	II,III,IV	+1.325	<.001	10	view →
HNSC	Male	III,IV	+1.040	<.001	10	view →
KIRP	Male	All	+1.333	<.001	9	view →
LIHC	All	II,III,IV	+0.794	<.001	8	view →
STAD	All	II,III,IV	+1.380	<.001	7	view →
BRCA	All	All	+1.605	<.001	6	view →
LUAD	Female	III,IV	+1.150	<.001	6	view →
CHOL	Female	All	+2.540	<.001	5	view →
READ	All	II,III,IV	+2.232	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

HAGHL–KICH

Open the KICH breakdown →