HAGHL

Across TCGA pan-cancer cohorts, HAGHL RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HAGHL data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher HAGHL RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HAGHL expression acts as an unfavorable survival marker, although some lineages such as KIRP and MESO show a favorable association.

UVM, KIRP, and UCS are the cancer types where HAGHL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.726	0.957	<.001	82	view →
KIRP	OS	Tertile	II,III,IV	0.742	0.306	.001	70	view →
UCS	DFS	Tertile	All	0.366	0.662	.009	64	view →
ACC	DFS	Median	All	0.426	0.733	.001	50	view →
KIRC	DFS	Quartile	All	0.780	0.934	.001	20	view →
SKCM	OS	Median	II,III,IV	0.176	0.528	<.001	19	view →
PRAD	DFS	Median	All	0.693	0.884	<.001	18	view →
COAD	OS	Quartile	II,III,IV	0.629	0.915	.002	17	view →
LIHC	OS	Median	All	0.478	0.634	.013	13	view →
MESO	DFS	Quartile	All	0.638	0.370	.020	12	view →
READ	DFS	Tertile	IV	0.918	0.434	.014	12	view →
THCA	OS	Tertile	IV	0.574	0.924	.018	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HAGHL–UVM (OS)

Open the UVM breakdown →