HAGH

Across TCGA patient cohorts, HAGH mutation is significantly associated with the RNA expression of many other genes, with 367 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAGH-associated genes across cancer lineages are RPS27P26, BNIP3P4, and HNRNPMP2. Each is linked with HAGH in more than 1 cancer types. Because this analysis shows association rather than direction, both HAGH-to-partner and partner-to-HAGH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS27P26 grouped by HAGH-low versus HAGH-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAGH→partner) and Y-score (partner→HAGH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPS27P26 →	+0.346	+5.343	<.001	.006	3	2
UCEC	BNIP3P4 →	+0.053	+3.069	.003	.009	3	2
SKCM	HNRNPMP2 →	+0.052	+4.680	<.001	.007	3	2
KIRC	RNA5SP524 →	+0.182	+8.025	<.001	.007	3	1
KIRC	RNU6-185P →	+0.193	+8.025	<.001	.007	3	1
SKCM	RNU6ATAC36P →	+0.696	+5.199	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 367 associations by consensus.

RPS27P26 by HAGH expression — LUAD

Explore this box plot interactively →