HAGH

Across TCGA pan-cancer cohorts, HAGH RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HAGH’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where HAGH RNA is repressed in tumor relative to normal tissue. In most cancer types HAGH is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and KIRP are the cancer types where HAGH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HAGH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	−0.520	<.001	9	view →
LUSC	All	III,IV	−0.976	<.001	8	view →
KIRP	Male	All	−0.699	<.001	8	view →
KICH	Male	All	−0.861	<.001	7	view →
BRCA	Female	All	+0.380	<.001	6	view →
CHOL	Male	All	−1.416	<.001	5	view →
KIRC	Male	All	−0.488	<.001	4	view →
BLCA	Male	III,IV	−0.527	.013	3	view →
THCA	All	All	+0.198	.003	3	view →
UCEC	All	III,IV	+0.424	.028	2	view →
COAD	Female	All	+0.356	.025	2	view →
LIHC	All	II,III,IV	−0.452	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HAGH–LUAD

Open the LUAD breakdown →