HAGH

Across TCGA cell cohorts, HAGH mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HAGH-associated genes across cancer lineages are OR11H2, CCDC182, and MMP26. Each is linked with HAGH in more than 1 cancer types. Because this analysis shows association rather than direction, both HAGH-to-partner and partner-to-HAGH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H2 grouped by HAGH-low versus HAGH-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAGH→partner) and Y-score (partner→HAGH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR11H2 →	+0.060	+5.201	<.001	.006	3	1
STOMACH	CCDC182 →	+0.033	+5.285	<.001	.003	3	1
STOMACH	MMP26 →	+0.673	+5.285	<.001	.003	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.378	+3.035	<.001	.003	3	1
LARGE_INTESTINE	FAM81B →	+0.238	+3.977	.003	.001	3	1
LARGE_INTESTINE	SAXO1 →	+0.039	+3.374	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

OR11H2 by HAGH expression — BLOOD_Leukemia

Explore this box plot interactively →