Across TCGA patient cohorts, HACD2 mutation is significantly associated with the RNA expression of many other genes, with 878 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HACD2-associated genes across cancer lineages are IGHD4-4, LINC02348, and ZNHIT3. Each is linked with HACD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HACD2-to-partner and partner-to-HACD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HACD2→partner) and Y-score (partner→HACD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGHD4-4 →	+2.045	+5.357	<.001	.006	3	2
UCEC	LINC02348 →	+0.294	+2.077	.009	.008	3	1
UCEC	ZNHIT3 →	+0.541	+3.828	.001	<.001	3	1
UCEC	INO80B-WBP1 →	+0.103	+2.992	.001	.001	3	1
UCEC	NUDT18 →	+0.623	+3.191	.006	.009	3	1
UCEC	MIR4734 →	+0.293	+2.224	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 878 associations by consensus.

Exploration

HACD2 survival (RNA) · tumor vs normal (RNA) · all HACD2 data types