Across TCGA patient cohorts, H4-16 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible H4-16-associated genes across cancer lineages are GOLGA6L1, SFPQP1, and TRAPPC2P7. Each is linked with H4-16 in more than 1 cancer types. Because this analysis shows association rather than direction, both H4-16-to-partner and partner-to-H4-16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H4-16→partner) and Y-score (partner→H4-16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GOLGA6L1 →	+0.015	+5.063	.001	.008	3	2
HNSC	SFPQP1 →	+0.034	+5.822	<.001	.003	3	2
BRCA	TRAPPC2P7 →	+0.203	+8.055	<.001	.007	3	2
OV	APOOP3 →	+0.057	+5.475	.001	.005	3	2
OV	B3GNTL1P2 →	+0.158	+5.676	<.001	.003	3	1
HNSC	MIR410 →	+0.335	+6.468	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Exploration

H4-16 survival (RNA) · tumor vs normal (RNA) · all H4-16 data types