H3P21

Across TCGA patient cohorts, H3P21 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,301 significant associations in total. STAD shows the largest number of these associations.

The most reproducible H3P21-associated GO terms across cancer lineages are Regulation of mitochondrial membrane potential, Vacuole organization, and Neuron projection extension. Each is linked with H3P21 in more than 7 cancer types. Because this analysis shows association rather than direction, both H3P21-to-partner and partner-to-H3P21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitochondrial membrane potential grouped by H3P21-low versus H3P21-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H3P21→partner) and Y-score (partner→H3P21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of mitochondrial membrane potential →	+0.124	+0.069	<.001	<.001	3	8
STAD	Vacuole organization →	+0.142	+0.078	<.001	<.001	3	8
STAD	Neuron projection extension →	+0.091	+0.064	<.001	<.001	3	8
STAD	Regulation of signal transduction by p53 class mediator →	+0.138	+0.070	<.001	<.001	3	8
STAD	Protein insertion into membrane →	+0.144	+0.078	<.001	<.001	3	8
STAD	Ribosomal small subunit biogenesis →	+0.167	+0.074	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,301 associations by consensus.

Regulation of mitochondrial membrane potential by H3P21 expression — STAD

Explore this box plot interactively →