Q-omics provides the consensus-scored H3P21 profile across patient tissues and cancer cell-line models. H3P21 expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in BLCA. Additionally, H3P21 RNA expression shows 9,826 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight BLCA, and THYM as cancer lineages where H3P21 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes H3P21 survival associations across molecular data types. H3P21 RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

H3P21 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	13	BLCA (165)	view →

This table ranks reproducible H3P21 RNA expression–survival associations across cancer types. High H3P21 expression shows unfavorable associations in BLCA, CESC, MESO, PCPG, UCEC and UVM. The BLCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify BLCA as the clearest survival context for H3P21 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	III,IV	0.169	0.557	<.001	165	view →
CESC	OS	Tertile	IV	0.091	0.593	<.001	66	view →
MESO	OS	Tertile	III,IV	0.098	0.579	.001	63	view →
PCPG	DFS	Tertile	All	0.641	0.906	<.001	33	view →
UCEC	OS	Tertile	All	0.881	0.937	.022	30	view →
UVM	OS	Tertile	All	0.294	0.791	.001	27	view →

Pink = unfavorable, green = favorable. all 13 lineages →

H3P21-BLCA (OS)

Kaplan–Meier survival curve for H3P21 RNA expression in BLCA: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with H3P21 in patient tissues and cancer cell lines. In patient samples, H3P21 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	9,826	THYM (3280)	view →
Function (RNA)	6,301	STAD (5084)	view →