H3P21

Across TCGA pan-cancer cohorts, H3P21 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated H3P21 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher H3P21 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H3P21 expression acts as an unfavorable survival marker, although some lineages such as UCS show a favorable association.

BLCA, CESC, and MESO are the cancer types where H3P21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	III,IV	0.169	0.557	<.001	165	view →
CESC	OS	Tertile	IV	0.091	0.593	<.001	66	view →
MESO	OS	Tertile	III,IV	0.098	0.579	.001	63	view →
PCPG	DFS	Tertile	All	0.641	0.906	<.001	33	view →
UCEC	OS	Tertile	All	0.881	0.937	.022	30	view →
UVM	OS	Tertile	All	0.294	0.791	.001	27	view →
THYM	OS	Tertile	III,IV	0.212	1.000	.014	18	view →
LGG	DFS	Tertile	All	0.660	0.856	.008	18	view →
LUAD	OS	Tertile	All	0.364	0.705	.001	18	view →
KIRC	DFS	Tertile	All	0.260	0.634	.018	12	view →
GBM	OS	Tertile	All	0.186	0.430	.013	9	view →
BRCA	DFS	Tertile	II,III,IV	0.425	0.523	.039	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

H3P21–BLCA (OS)

Open the BLCA breakdown →