H3C7

Across TCGA cell cohorts, H3C7 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,922 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H3C7-associated GO terms across cancer lineages are Negative regulation of metaphase/anaphase transition of cell cycle, Negative regulation of chromosome separation, and Antibacterial humoral response. Each is linked with H3C7 in more than 6 cancer types. Because this analysis shows association rather than direction, both H3C7-to-partner and partner-to-H3C7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of metaphase/anaphase transition of cell cycle grouped by H3C7-low versus H3C7-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C7→partner) and Y-score (partner→H3C7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.059	+0.367	.008	.006	3	7
LUNG_NSCLC_LUAD	Negative regulation of chromosome separation →	+0.059	+0.367	.008	.006	3	7
LUNG_NSCLC_LUSC	Antibacterial humoral response →	-0.215	-0.852	<.001	.004	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of meiotic cell cycle →	+0.080	+0.686	.007	.006	2	7
URINARY_TRACT	Positive regulation of chromosome segregation →	+0.126	+0.545	.001	<.001	3	6
URINARY_TRACT	Regulation of spindle checkpoint →	+0.131	+0.592	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,922 associations by consensus.

Negative regulation of metaphase/anaphase transition of cell cycle by H3C7 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →