H3-4

Across TCGA patient cohorts, H3-4 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,087 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible H3-4-associated proteins across cancer lineages are RPRD2, SDE2, and DIDO1. Each is linked with H3-4 in more than 3 cancer types. Because this analysis shows association rather than direction, both H3-4-to-partner and partner-to-H3-4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, H3-4 versus RPRD2 in UCEC, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-4→partner) and Y-score (partner→H3-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPRD2 →	+0.263	+0.570	<.001	<.001	3	4
UCEC	SDE2 →	+0.290	+0.617	<.001	<.001	3	4
GBM	DIDO1 →	+0.250	+0.527	.005	.005	3	4
OV	GGPS1 →	+0.401	+0.325	<.001	.006	3	3
LSCC	PRCC →	+0.273	+0.455	<.001	<.001	3	3
HNSC	PRCC_S267 →	+0.271	+0.437	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,087 associations by consensus.

H3-4 vs RPRD2 — UCEC

Explore this scatter interactively →