H3-4

Across TCGA pan-cancer cohorts, H3-4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of H3-4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where H3-4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H3-4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRP, KIRC, and CHOL are the cancer types where H3-4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3-4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	All	+0.232	.001	6	view →
KIRC	All	All	+0.071	<.001	5	view →
CHOL	Male	All	+0.483	.003	4	view →
HNSC	All	II,III,IV	+0.041	.027	3	view →
BLCA	Female	IV	+0.426	.004	2	view →
ESCA	All	II,III,IV	+0.225	.023	2	view →
LIHC	All	All	+0.021	.007	2	view →
READ	All	All	+0.182	.038	1	view →
STAD	All	All	+0.154	.046	1	view →
THCA	All	All	−0.051	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

H3-4–KIRP

Open the KIRP breakdown →