H3-4

Across TCGA pan-cancer cohorts, H3-4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated H3-4 data layer compared with 2 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher H3-4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H3-4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

ACC, THYM, and KIRC are the cancer types where H3-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Quartile	All	0.536	0.932	<.001	63	view →
THYM	OS	Quartile	All	0.554	1.000	<.001	40	view →
KIRC	OS	Tertile	II,III,IV	0.878	0.767	.004	39	view →
HNSC	DFS	Quartile	All	0.404	0.287	.010	36	view →
COAD	OS	Median	II,III,IV	0.778	0.911	.002	35	view →
STAD	OS	Tertile	III,IV	0.645	0.209	<.001	32	view →
KICH	DFS	Quartile	All	0.711	0.927	.012	31	view →
UVM	DFS	Tertile	III,IV	0.079	0.635	.021	27	view →
PRAD	OS	Tertile	All	0.978	1.000	<.001	20	view →
KIRP	DFS	Quartile	All	0.330	0.720	<.001	20	view →
MESO	OS	Tertile	II,III,IV	0.224	0.695	.003	18	view →
READ	DFS	Median	III,IV	0.310	0.749	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

H3-4–ACC (OS)

Open the ACC breakdown →