H3-4

Across TCGA patient cohorts, H3-4 mutation is significantly associated with the RNA expression of many other genes, with 725 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H3-4-associated genes across cancer lineages are RNU6-906P, TRAJ19, and NPIPA2. Each is linked with H3-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3-4-to-partner and partner-to-H3-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-906P grouped by H3-4-low versus H3-4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-4→partner) and Y-score (partner→H3-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-906P →	+0.234	+3.330	.007	.008	3	2
LUAD	TRAJ19 →	+0.798	+4.130	.004	.001	3	2
LUAD	NPIPA2 →	+0.018	+4.590	<.001	.004	3	2
UCEC	SAR1AP4 →	+0.149	+2.656	.002	.003	3	2
UCEC	F8A2 →	+0.039	+3.279	<.001	.006	3	2
UCEC	RNA5SP85 →	+0.988	+3.121	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 725 associations by consensus.

RNU6-906P by H3-4 expression — LUAD

Explore this box plot interactively →