H3-4

Across TCGA patient cohorts, H3-4 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H3-4-associated genes across cancer lineages are GATA6, INPP4B, and MEK1. Each is linked with H3-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3-4-to-partner and partner-to-H3-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by H3-4-low versus H3-4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-4→partner) and Y-score (partner→H3-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.187	-3.000	.020	.035	3	1
UCEC	INPP4B →	-0.368	-3.308	.029	.010	3	1
UCEC	MEK1 →	+0.562	+3.321	.003	.010	3	1
UCEC	PDCD4 →	-0.776	-3.169	.001	.018	3	1
UCEC	PKC-delta_pS664 →	-0.138	-2.999	.028	.035	3	1
UCEC	STAT3_pY705 →	-0.464	-2.999	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GATA6 by H3-4 expression — UCEC

Explore this box plot interactively →