H3-4

Across TCGA cell cohorts, H3-4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,765 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H3-4-associated GO terms across cancer lineages are Cytosolic transport, mRNA splice site recognition, and Negative regulation of DNA-templated transcription initiation. Each is linked with H3-4 in more than 10 cancer types. Because this analysis shows association rather than direction, both H3-4-to-partner and partner-to-H3-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytosolic transport grouped by H3-4-low versus H3-4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-4→partner) and Y-score (partner→H3-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.060	+0.263	<.001	.009	3	11
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.133	+0.377	<.001	.003	3	10
BLOOD_Leukemia	Negative regulation of DNA-templated transcription initiation →	+0.078	+0.190	.002	<.001	3	10
BLOOD_Leukemia	Negative regulation of transcription initiation by RNA polymerase II →	+0.078	+0.190	.002	<.001	3	10
BONE	Regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.066	+0.093	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Retrograde transport, endosome to Golgi →	+0.071	+0.366	<.001	.007	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,765 associations by consensus.

Cytosolic transport by H3-4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →