H3-4

Across TCGA cell cohorts, H3-4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible H3-4-associated genes across cancer lineages are OR7C2, C1QL2, and MAGEB4. Each is linked with H3-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3-4-to-partner and partner-to-H3-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7C2 grouped by H3-4-low versus H3-4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-4→partner) and Y-score (partner→H3-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR7C2 →	+0.026	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	C1QL2 →	+0.012	+4.922	<.001	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	DAZ2 →	+0.252	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR7C2 by H3-4 expression — BLOOD_Leukemia

Explore this box plot interactively →