H3-3B

Across TCGA patient cohorts, H3-3B mutation is significantly associated with the RNA expression of many other genes, with 976 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H3-3B-associated genes across cancer lineages are PSAT1P4, PCGF6, and PCBD1. Each is linked with H3-3B in more than 2 cancer types. Because this analysis shows association rather than direction, both H3-3B-to-partner and partner-to-H3-3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSAT1P4 grouped by H3-3B-low versus H3-3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-3B→partner) and Y-score (partner→H3-3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSAT1P4 →	+0.179	+2.241	.001	.005	3	3
UCEC	PCGF6 →	+0.576	+3.617	.008	.001	3	2
UCEC	PCBD1 →	+0.626	+3.584	<.001	.003	3	2
CESC	RNA5SP394 →	+0.459	+5.345	<.001	.001	3	2
SKCM	RNU6-906P →	+0.188	+3.513	<.001	<.001	3	2
SKCM	RNU6-739P →	+0.098	+3.897	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 976 associations by consensus.

PSAT1P4 by H3-3B expression — UCEC

Explore this box plot interactively →