H3-3B

Across TCGA pan-cancer cohorts, H3-3B RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of H3-3B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H3-3B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H3-3B is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where H3-3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3-3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.639	<.001	11	view →
KICH	Female	II,III,IV	−2.840	<.001	9	view →
LIHC	All	III,IV	+0.753	<.001	9	view →
UCEC	All	All	−0.775	<.001	6	view →
CHOL	Male	All	+1.941	<.001	5	view →
PRAD	All	All	−0.261	.010	2	view →
LUAD	All	All	−0.195	.004	2	view →
ESCA	All	All	+0.752	.048	1	view →
COAD	Male	All	+0.194	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

H3-3B–HNSC

Open the HNSC breakdown →