H3-3B

Across TCGA pan-cancer cohorts, H3-3B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated H3-3B data layer compared with 5 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher H3-3B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H3-3B expression acts as an unfavorable survival marker, although some lineages such as KIRC and COAD show a favorable association.

ACC, KIRP, and KIRC are the cancer types where H3-3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.243	0.701	<.001	85	view →
KIRP	DFS	Quartile	III,IV	0.375	0.900	<.001	84	view →
KIRC	DFS	Tertile	III,IV	0.765	0.528	.017	24	view →
KICH	OS	Quartile	II,III,IV	0.649	1.000	.013	24	view →
PAAD	OS	Quartile	All	0.343	0.593	.017	22	view →
THCA	DFS	Tertile	IV	0.679	0.951	.020	13	view →
COAD	OS	Tertile	II,III,IV	0.863	0.739	.021	12	view →
LIHC	DFS	Median	All	0.485	0.596	.025	9	view →
BRCA	OS	Median	III,IV	0.944	0.859	.005	8	view →
SKCM	OS	Tertile	II,III,IV	0.518	0.186	.023	8	view →
MESO	OS	Tertile	III,IV	0.498	0.712	.018	7	view →
HNSC	OS	Median	III,IV	0.683	0.763	.014	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

H3-3B–ACC (DFS)

Open the ACC breakdown →