H3-3B

Across TCGA patient cohorts, H3-3B mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H3-3B-associated genes across cancer lineages are Ku80, FOXO3a_pS318_S321, and ACC1. Each is linked with H3-3B in more than 1 cancer types. Because this analysis shows association rather than direction, both H3-3B-to-partner and partner-to-H3-3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by H3-3B-low versus H3-3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-3B→partner) and Y-score (partner→H3-3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.404	+3.472	<.001	.002	3	2
UCEC	FOXO3a_pS318_S321 →	-0.197	-3.169	.001	.018	3	1
UCEC	ACC1 →	+0.513	+3.013	.004	.018	3	1
UCEC	p62 Lck ligand →	+0.456	+2.179	.005	.034	3	1
UCEC	Rab11 →	-0.185	-3.459	.011	.005	3	1
UCEC	Tuberin →	+0.357	+2.817	.008	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Ku80 by H3-3B expression — UCEC

Explore this box plot interactively →