H3-3B

Across TCGA cell cohorts, H3-3B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,577 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H3-3B-associated GO terms across cancer lineages are Negative regulation of cell cycle process, Positive regulation of mitotic cytokinesis, and Nuclear envelope organization. Each is linked with H3-3B in more than 11 cancer types. Because this analysis shows association rather than direction, both H3-3B-to-partner and partner-to-H3-3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle process grouped by H3-3B-low versus H3-3B-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-3B→partner) and Y-score (partner→H3-3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Negative regulation of cell cycle process →	+0.062	+1.345	.001	.003	2	12
BREAST	Positive regulation of mitotic cytokinesis →	+0.150	+1.166	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Nuclear envelope organization →	+0.083	+0.678	.002	.005	3	11
LUNG_SCLC	Sulfur compound metabolic process →	-0.045	-0.521	.005	.006	3	10
CNS	Regulation of microtubule cytoskeleton organization →	+0.039	+0.561	<.001	<.001	3	10
OVARY	Positive regulation of spindle checkpoint →	+0.091	+0.756	<.001	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,577 associations by consensus.

Negative regulation of cell cycle process by H3-3B expression — BLOOD_Myeloma

Explore this box plot interactively →