H3-3B

Across TCGA cell cohorts, H3-3B mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H3-3B-associated genes across cancer lineages are EPPIN, OR5P3, and FAM47A. Each is linked with H3-3B in more than 1 cancer types. Because this analysis shows association rather than direction, both H3-3B-to-partner and partner-to-H3-3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPPIN grouped by H3-3B-low versus H3-3B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-3B→partner) and Y-score (partner→H3-3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	OR5P3 →	+0.111	+5.201	<.001	.006	3	1
BLOOD_Leukemia	FAM47A →	+0.041	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

EPPIN by H3-3B expression — BLOOD_Leukemia

Explore this box plot interactively →