H2BW2

Across TCGA patient cohorts, H2BW2 mutation is significantly associated with the RNA expression of many other genes, with 333 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2BW2-associated genes across cancer lineages are RN7SL134P, RNA5SP182, and MIR6857. Each is linked with H2BW2 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BW2-to-partner and partner-to-H2BW2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by H2BW2-low versus H2BW2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BW2→partner) and Y-score (partner→H2BW2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL134P →	+0.201	+4.874	<.001	.002	3	2
BRCA	RNA5SP182 →	+1.228	+9.057	<.001	.003	3	2
UCEC	MIR6857 →	+0.242	+2.773	.004	.004	3	1
UCEC	PLA2G3 →	+0.881	+2.807	.002	.003	3	1
UCEC	FBXO7 →	+0.429	+3.210	.005	.009	3	1
UCEC	PHF5A →	+0.469	+3.516	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 333 associations by consensus.

RN7SL134P by H2BW2 expression — CESC

Explore this box plot interactively →