H2BW2

Across TCGA pan-cancer cohorts, H2BW2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of H2BW2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H2BW2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2BW2 is over-expressed in tumor, although a few such as PRAD and THCA show the opposite, repressed pattern.

HNSC, LUSC, and BLCA are the cancer types where H2BW2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2BW2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.123	<.001	8	view →
LUSC	All	All	+0.255	<.001	7	view →
BLCA	All	All	+0.303	.021	2	view →
COAD	All	II,III,IV	+0.034	.031	2	view →
PRAD	All	All	−0.017	.048	2	view →
STAD	All	All	+0.046	.031	1	view →
THCA	Male	All	−0.012	.049	1	view →
KIRC	Male	All	+0.010	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

H2BW2–HNSC

Open the HNSC breakdown →