H2BW2

Across TCGA pan-cancer cohorts, H2BW2 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated H2BW2 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher H2BW2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H2BW2 expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCS show a favorable association.

UVM, SCLC, and UCEC are the cancer types where H2BW2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.275	0.940	<.001	54	view →
SCLC	OS	Median	II,III,IV	0.605	0.267	<.001	54	view →
UCEC	OS	Tertile	All	0.883	0.945	.001	44	view →
UCS	DFS	Median	II,III,IV	0.534	0.176	<.001	40	view →
THCA	OS	Tertile	IV	0.095	0.966	<.001	27	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
LUSC	DFS	Tertile	III,IV	0.368	0.684	.005	25	view →
ACC	DFS	Tertile	IV	0.763	0.256	.034	9	view →
LUAD	OS	Tertile	II,III,IV	0.837	0.681	.031	6	view →
KIRP	OS	Tertile	II,III,IV	1.000	0.600	.030	6	view →
ESCA	DFS	Median	All	0.230	0.384	.046	4	view →
HNSC	DFS	Median	All	0.280	0.414	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

H2BW2–UVM (OS)

Open the UVM breakdown →