H2BW2

Across TCGA patient cohorts, H2BW2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2BW2-associated genes across cancer lineages are EGFR_pY1068, JNK2, and Annexin-1. Each is linked with H2BW2 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BW2-to-partner and partner-to-H2BW2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by H2BW2-low versus H2BW2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BW2→partner) and Y-score (partner→H2BW2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.305	-2.459	.011	.020	3	1
UCEC	JNK2 →	+0.198	+3.009	.039	.019	3	1
UCEC	Annexin-1 →	+0.625	+2.827	.014	.035	3	1
UCEC	VHL →	-0.941	-2.459	.004	.020	3	1
UCEC	4E-BP1 →	+0.313	+3.029	.016	.018	3	1
UCEC	p62 Lck ligand →	+0.399	+3.179	.011	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR_pY1068 by H2BW2 expression — UCEC

Explore this box plot interactively →