Across TCGA patient cohorts, H2BU1 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2BU1-associated genes across cancer lineages are TRIM77, MIR1252, and RNU6-1286P. Each is linked with H2BU1 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BU1-to-partner and partner-to-H2BU1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BU1→partner) and Y-score (partner→H2BU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRIM77 →	+0.049	+5.888	.005	.002	3	2
CESC	MIR1252 →	+0.622	+5.669	<.001	.003	3	1
HNSC	RNU6-1286P →	+0.368	+7.954	<.001	.008	3	1
HNSC	MIR548F2 →	+0.398	+7.954	<.001	.008	3	1
UCEC	RNU1-68P →	+0.126	+4.292	<.001	.006	3	1
UCEC	MIR6858 →	+1.145	+4.137	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Exploration

H2BU1 survival (RNA) · tumor vs normal (RNA) · all H2BU1 data types